David A Hart Selected Research

Contracture

1/2021	The Dose-Response Effect of the Mast Cell Stabilizer Ketotifen Fumarate on Posttraumatic Joint Contracture: An in Vivo Study in a Rabbit Model.
1/2020	Human serum mast cell tryptase levels in elbow fractures or dislocations and its association with injury severity.
3/2017	Serum Mast Cell Tryptase as a Marker of Posttraumatic Joint Contracture in a Rabbit Model.
10/2014	A myofibroblast-mast cell-neuropeptide axis of fibrosis in post-traumatic joint contractures: an in vitro analysis of mechanistic components.
11/2013	Posttraumatic elbow contractures: targeting neuroinflammatory fibrogenic mechanisms.
4/2012	The mast cell stabilizer ketotifen reduces joint capsule fibrosis in a rabbit model of post-traumatic joint contractures.
6/2010	The mast cell stabilizer ketotifen fumarate lessens contracture severity and myofibroblast hyperplasia: a study of a rabbit model of posttraumatic joint contractures.
10/2008	Joint capsule mast cells and neuropeptides are increased within four weeks of injury and remain elevated in chronic stages of posttraumatic contractures.
2/2008	Cellular, matrix, and growth factor components of the joint capsule are modified early in the process of posttraumatic contracture formation in a rabbit model.
3/2007	Myofibroblast upregulators are elevated in joint capsules in posttraumatic contractures.

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David A Hart Research Topics

Disease

15	Inflammation (Inflammations) 04/2021 - 09/2005
15	Cicatrix (Scar) 01/2011 - 05/2002
13	Contracture 01/2021 - 02/2004
12	Osteoarthritis 01/2021 - 05/2002
10	Wounds and Injuries (Trauma) 01/2020 - 01/2007
9	Obesity 12/2021 - 12/2012
9	Fibrosis (Cirrhosis) 05/2017 - 03/2008
5	Pain (Aches) 04/2021 - 01/2012
4	Insulin Resistance 12/2021 - 01/2018
4	Tendinopathy (Tendonitis) 08/2015 - 03/2007
4	Arthritis (Polyarthritis) 07/2012 - 01/2007
3	Knee Osteoarthritis 12/2021 - 01/2019
3	Rupture 01/2018 - 02/2009
3	Tendon Injuries 03/2017 - 10/2006
2	Atrophy 01/2018 - 05/2017
2	Knee Injuries (Knee Injury) 01/2017 - 06/2016
2	Joint Diseases (Joint Disease) 01/2014 - 04/2007
2	Hyperplasia 06/2010 - 07/2008
2	Rotator Cuff Injuries 06/2005 - 07/2004
1	Thrombosis (Thrombus) 01/2022
1	Morbid Obesity 04/2021
1	Chronic Disease (Chronic Diseases) 01/2021
1	Elbow Fractures 01/2020
1	Intervertebral Disc Degeneration 02/2019
1	Back Pain (Backache) 02/2019
1	Intraoperative Complications 01/2019
1	Dyslipidemias (Dyslipidemia) 01/2019
1	Hemarthrosis 01/2019
1	Endotoxemia 01/2019
1	Maternal Obesity 01/2019
1	Metabolic Diseases (Metabolic Disease) 01/2019
1	Fatty Liver 01/2019
1	Hemorrhage 01/2019
1	Bell Palsy (Bell's Palsy) 03/2018
1	Hypercholesterolemia 01/2018
1	Anterior Cruciate Ligament Injuries 01/2018
1	Pelvic Organ Prolapse 02/2016
1	Muscle Spasticity (Spastic) 07/2015

Drug/Important Bio-Agent (IBA)

26	Messenger RNA (mRNA)IBA 01/2021 - 05/2002
11	CollagenIBA 01/2013 - 09/2005
9	CytokinesIBA 04/2021 - 08/2005
8	Proteins (Proteins, Gene)FDA Link 01/2022 - 02/2004
7	Sucrose (Saccharose)IBA 12/2021 - 01/2016
7	NeuropeptidesIBA 02/2019 - 07/2007
7	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 03/2017 - 08/2005
6	PrebioticsIBA 12/2021 - 01/2019
5	Ketotifen (Ketotifene)FDA Link 01/2021 - 03/2008
5	GlucocorticoidsIBA 01/2018 - 09/2005
5	Transforming Growth Factor beta (TGF-beta)IBA 11/2013 - 05/2002
5	DecorinIBA 05/2006 - 05/2002
4	AdipokinesIBA 04/2021 - 08/2015
4	Substance PIBA 01/2021 - 07/2007
4	Mast Cell StabilizersIBA 01/2021 - 03/2008
4	BiglycanIBA 10/2005 - 05/2002
3	LipidsIBA 12/2021 - 08/2015
3	Tryptases (Tryptase)IBA 01/2020 - 04/2012
3	Dexamethasone (Maxidex)FDA LinkGeneric 01/2019 - 12/2015
3	Matrix Metalloproteinases (MMPs)IBA 07/2012 - 07/2004
3	RNA (Ribonucleic Acid)IBA 07/2008 - 05/2002
3	Collagen Type I (Type I Collagen)IBA 02/2003 - 05/2002
2	oligofructoseIBA 04/2021 - 01/2019
2	Biological ProductsIBA 01/2021 - 01/2017
2	Hormones (Hormone)IBA 01/2021 - 01/2014
2	Biomarkers (Surrogate Marker)IBA 01/2020 - 01/2015
2	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 01/2018
2	Methylprednisolone Acetate (Depo-Medrol)FDA LinkGeneric 01/2018 - 03/2017
2	Calcitonin Gene-Related PeptideIBA 01/2012 - 07/2007
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2010 - 05/2002
2	Fibronectins (Fibronectin)IBA 09/2009 - 03/2007
2	AntigensIBA 08/2009 - 01/2007
2	Transforming Growth Factor beta1 (TGF beta 1)IBA 06/2009 - 03/2007
2	Tissue Inhibitor of Metalloproteinase-1IBA 08/2007 - 05/2006
2	LumicanIBA 05/2006 - 05/2002
2	Collagen Type III (Type III Collagen)IBA 06/2005 - 02/2003
1	Dietary Fiber FDA Link 04/2021
1	Inulin FDA Link 04/2021
1	maltodextrinIBA 04/2021
1	Dichlorodiphenyldichloroethane (DDD)IBA 02/2019
1	LeptinIBA 01/2019
1	Dietary Sucrose (Table Sugar)IBA 01/2019
1	EndotoxinsIBA 01/2019
1	SteroidsIBA 03/2018
1	PlasticsIBA 01/2018
1	CholesterolIBA 01/2018
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2018
1	incobotulinumtoxinA FDA Link 01/2018
1	Myosin Heavy Chains (Myosin Heavy Chain)IBA 05/2017
1	Glycoproteins (Glycoprotein)IBA 03/2017
1	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 03/2017
1	lubricinIBA 03/2017
1	SugarsIBA 11/2016
1	Progesterone FDA LinkGeneric 02/2016
1	Type A Botulinum Toxins (Botox)FDA Link 07/2015

Therapy/Procedure

5	Therapeutics 07/2018 - 02/2004
3	Injections 01/2018 - 07/2015
2	Replacement Arthroplasty 04/2021 - 12/2012
2	Activities of Daily Living (ADL) 01/2021 - 01/2018
1	Conservative Treatment 04/2021
1	Bed Rest (Bedrest) 01/2021
1	Intra-Articular Injections 01/2018